Advancing precision medicine with molecular glues

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Magnet Biomedicine’s modular TrueGlue™ technology enables the systematic discovery of molecular glues towards the treatment of human disease.

Our technology builds upon the discoveries of our Scientific Founders, who provided the seminal observations on molecular glues and have explored them for over 30 years.

THE SCIENCE

TrueGlues are small molecules that localize drug effects to disease-relevant targets in complex with tissue enriched “presenter” proteins

Magnet is advancing precision medicine through rational selection of protein pairs and systematic design of monovalent molecular glues. Combining the benefits of small molecule drugs with the high specificity of antibodies, TrueGlues offer the potential to address the most challenging targets in a tissue localized manner.

Abstract representation of a TrueGlue molecule facilitating binding of a target protein with a presenter protein.
Abstract representation of a TrueGlue molecule facilitating binding of a target protein with a presenter protein.
TrueGlues induce pairing of a target with a presenter protein to achieve therapeutic effects.
TrueGlues induce binding between target and presenter proteins only in tissues enriched with presenter proteins, minimizing toxicity.
TrueGlues induce binding between target and presenter proteins only in tissues enriched with presenter proteins, minimizing toxicity.
TrueGlues enable tissue-specific target inhibition to minimize toxicity.

Since their discovery more than three decades ago, molecular glues have demonstrated vast potential to treat human disease. Recent advancements in the field have largely focused on targeted protein degradation, leaving the expansive potential of molecular glues untapped. Magnet is reimagining what’s possible with molecular glues by venturing beyond known protein-protein interactions and analyzing the broad protein landscape to pair target proteins with endogenous presenter proteins for maximum therapeutic impact.

Uniquely enabled by its platform capabilities, Magnet is pioneering the discovery of novel molecular glue medicines to address a range of indications with high unmet need, including cardiovascular disease, cancer, and immune disorders.

Rationally designed TrueGlues localize drug effects to disease-relevant tissues, providing unique opportunities to maximize the therapeutic index by minimizing on-target-off-tissue toxicity. TrueGlues offer opportunities to induce biological synergy, target historically undruggable proteins, and to mimic monoclonal antibodies—enabling small molecule inhibition of extracellular targets.

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OUR TECHNOLOGY

Building upon recent advances in proteomics, screening, and bioinformatics, we believe the time is now to execute on this long-standing goal of rational molecular glue discovery

Our TrueGlue discovery platform combines state-of-the-art screening technologies utilizing diverse chemical libraries and human-biology-driven target selection. Our process integrates diverse streams of in-house and external data to discover and exploit novel molecular glue mechanisms of action.  Magnet’s TrueGlue technology can be applied in an indication-agnostic manner to discover molecular glues with a wide range of target modulation, drug-like properties, and selectivity.  

OUR PEOPLE

Brian Safina
Brian Safina, Ph.D.
President & Chief Scientific Officer
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Bret Williams
Bret Williams, Ph.D.
Vice President of Biology
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Matthew Hayward
Matthew Hayward, Ph.D.
Vice President of Drug Discovery
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Jennifer Franklin
Jennifer Franklin
Vice President of Administration & Operations
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Kristina Burow
Kristina Burow
Managing Director at ARCH Venture Partners
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Thomas Cahill
Thomas Cahill, M.D., Ph.D.
Founder and Managing Partner at Newpath Partners
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Ramnik Xavier
Ramnik Xavier, M.D., Ph.D.
Scientific Advisory Board Chair
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Benjamin F. Cravatt, Ph.D
Benjamin F. Cravatt, Ph.D.
Founder & Advisor
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David Spiegel
David A. Spiegel, M.D., Ph.D.
Founder & Advisor
Michael Rosbash
Michael Rosbash, Ph.D.
Founder & Advisor
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Richa Saxena
Richa Saxena, Ph.D.
Founder & Advisor
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Stuart Schreiber, Ph.D
Stuart Schreiber, Ph.D.
Founder & Advisor
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Chelsea Ankeny
Chelsea Ankeny
Office Manager
Austin Carr, PhD
Austin Carr, Ph.D.
Proteomics
Xiao Chen
Xiao Chen, Ph.D.
Biology
YiQun Chen
YiQun Chen
Biology
Jessica Gasser
Jessica Gasser, Ph.D.
Biology
Shubhroz Gill
Shubhroz Gill, Ph.D.
Biology
Bruce Hua
Bruce Hua, Ph.D.
Chemistry
Liam Hudson
Liam Hudson, Ph.D.
Chemistry
Anita Kim
Anita Kim
Lab Operations
Chueh-Ling Kuo
Chueh-Ling Kuo, Ph.D.
Biomolecular Discovery
Jason Lowe, Ph.D.
Jason Lowe, Ph.D.
Chemistry
Alyssa Lutservitz
Alyssa Lutservitz, MS
Informatics
Ashish Maurya
Ashish Maurya, Ph.D.
Biology
Francesca Pisanzio
Francesca Pisanzio
Biology
James Ralff
James Ralff
Compound Management
Andrew Reidenbach
Andrew Reidenbach, Ph.D.
Biomolecular Discovery
David Rhee, PhD
David Rhee, Ph.D.
Proteomics
Luke Stamatakis
Luke Stamatakis
Finance & Accounting
Tom Tian, PhD
Tom Tian, Ph.D.
Biology
Tiffany Tsang
Tiffany Tsang, Ph.D.
Biology
Go Watanabe, PhD
Go Watanabe, Ph.D.
Protein Production
Hsin-Lan Wen
Hsin-Lan Wen, Ph.D.
Biology

OUR INVESTORS

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CAREERS

Magnet Biomedicine is building a world-class team to unleash the scientific breakthroughs and expertise of our Founders.

We are looking for creative, thoughtful, science-first innovators to join our collaborative team. Come help us realize the potential of molecular glues to achieve the broadest possible impact for patients.

Click the job openings to learn more.

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NEWS

The latest Magnet news and presentations

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09.19.2023

Magnet Biomedicine Emerges from Stealth with $50 Million to Advance Rational Approach to Molecular Glues with TrueGlue™ Discovery Platform

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